检索范围:
排序: 展示方式:
Atypical pituitary hormone–target tissue axis
《医学前沿(英文)》 2023年 第17卷 第1期 页码 1-17 doi: 10.1007/s11684-022-0973-7
关键词: thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone prolactin
Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani
《医学前沿(英文)》 2021年 第15卷 第1期 页码 101-107 doi: 10.1007/s11684-020-0752-2
关键词: iatrogenic primary hypothyroidism late effects of radiotherapy long-term follow-up medulloblastoma Hodgkin lymphoma
Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng
《医学前沿(英文)》 2018年 第12卷 第5期 页码 580-585 doi: 10.1007/s11684-017-0585-9
This study aimed to evaluate the effects of thyroid hormone supplementation on growth rate of children with idiopathic short stature (ISS) and low-normal serum free thyroxine FT4 who were receiving growth hormone therapy. We selected 64 prepubertal children with FT4 levels in the lowest third of the normal range as the lower FT4 group, and these children were divided randomly into two subgroups: L-thyroxine (L-T4)-treated subgroup was treated with L-T4 (0.5–3.0 g/(kg·d)) from the beginning of the study, and the non-L-T4-treated subgroup received placebo. We also selected 39 ISS children with FT4 in the upper two-thirds of the normal range as the higher FT4 group. During the first year, the lower FT4 group featured lower FT3, FT4, thyroid stimulating hormone (TSH), and insulin-like growth factor-I standard deviation score (IGF-I SDS) and significantly lower height velocity (HV) compared with the higher FT4 group. However, in the lower FT4 group, the L-T4-treated subgroup presented higher FT4, FT3, TSH, and IGF-I SDS concentrations and significantly higher HV compared with children in the non-L-T4-treated subgroup. In children with ISS, the negative effect of thyroid hormone deficiency on growth rate should be considered when FT4 level lies in the low-normal range prior to recombinant human growth hormone treatment.
关键词: therapeutic idiopathic short-stature children free T4 the first year recombinant human growth hormone
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 359-364 doi: 10.1007/s11684-017-0528-5
Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder. The most serious complication of TAO is dysthyroid optic neuropathy (DON), which can lead to permanent vision loss because of volume expansion in the orbital apex. Orbital radiation therapy (ORT) is an anti-inflammatory treatment used in the treatment of active TAO. Clinical studies support radiotherapy as having a modest effect on DON, and early radiotherapy may protect against disease progression to DON. Current studies suggest that radiotherapy is generally safe. However, risks still exist in some cases. The possible effects of radiotherapy on TAO, especially complicated with DON, are reviewed. The effects of radiotherapy on DON are not completely known, and evidence from standardized, prospective, and multicenter clinical trials is still lacking.
关键词: thyroid-associated orbitopathy dysthyroid optic neuropathy orbital radiation therapy
Ling HOU, Xiaoping LUO, Minlian DU, Huamei MA, Chunxiu GONG, Yuchuan LI, Shuixian SHEN, Zhuhui ZHAO, Li LIANG, Guanping DONG, Chaoying YAN, Hongwei DU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 171-176 doi: 10.1007/s11684-009-0027-4
关键词: recombinant human growth hormone injection growth hormone deficiency
How to judge the association of postmenopausal hormone therapy and the risk of breast cancer
Ling XU
《医学前沿(英文)》 2010年 第4卷 第3期 页码 290-293 doi: 10.1007/s11684-010-0093-7
关键词: breast cancer postmenopausal hormone therapy unopposed estrogen therapy combined estrogen-progestin therapy
Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 113-117 doi: 10.1007/s11684-014-0310-x
Papillary thyroid carcinoma (PTC) is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 (located at the 14q13.3 locus), which was probably the genetic risk factor of PTC. This study aimed to examine the association of this gene with PTC in Chinese. A total of 354 patients with PTC and 360 healthy control subjects from the Han population of Northern China were recruited in the study. These individuals were genotyped to determine rs12589672, rs12894724, rs2076751, and rs944289. The association of rs944289 with PTC was obtained (C vs. T, P=0.027, OR=1.264, 95% CI=1.026-1.557; and C/C-C/T vs. T/T, P=0.034, OR=1.474, 95% CI=1.028-2.112). Conducting a subgroup analysis, we found a marginal difference in the allele frequency distribution of rs944289 (adjusted P=0.062) between the patients with PTC and multi-nodular goiter and the control subjects. We also observed an interaction (P=0.029; OR=2.578, 95% CI=1.104-6.023) between rs944289 and diabetes in patients with PTC. In conclusion, rs944289 was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.
关键词:
黄培,黄勋彬
《中国工程科学》 2015年 第17卷 第6期 页码 16-20
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities. It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network. Much is known about ethylene, one of the most important metabolites promoting the ripening of climacteric fruits. However, the dynamic interplay between phytohormones also plays an important part. Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening. Here, we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.
关键词: climacteric fruit ripening / phytohormones / TFs / epigenetic modifications
Yinglin JI, Mingyang XU, Aide WANG
《农业科学与工程前沿(英文)》 页码 314-334 doi: 10.15302/J-FASE-2021386
关键词: climacteric fruit ripening phytohormones TFs epigenetic modifications
JU Ying, CHEN Lan, JIANG Qi, YANG Kedi, CHEN Xuemin, XU Guojian, LI Liping
《医学前沿(英文)》 2008年 第2卷 第3期 页码 276-282 doi: 10.1007/s11684-008-0052-8
《医学前沿(英文)》 doi: 10.1007/s11684-023-0999-5
关键词: thyroid carcinoma mesenchymal stem cell extracellular vesicle GTF2I FAT1 CDK4
甲状腺乳头状癌菌群失调及与肿瘤信号通路异常的相关性研究 Article
喻爽, 丁彦强, 王雪洁, Siu Kin Ng, 曹思婷, 刘伟鑫, 郭朱明, 谢宇彬, 洪澍彬, 许丽霞, 李晓星, 李杰, 吕伟明, 彭穗, 李延兵, 沈祖尧, 于君, 肖海鹏
《工程(英文)》 2023年 第28卷 第9期 页码 179-192 doi: 10.1016/j.eng.2023.01.007
研究表明微生态失调在多种肿瘤的发生发展中起至关重要的作用。然而,对于甲状腺肿瘤中细菌是否参与肿瘤的发生仍不清楚。本研究中,我们旨在探索甲状腺组织中的菌群特征及其对甲状腺乳头状癌(PTC)的作用。我们同时对 340 例PTC和甲状腺良性结节 (BTN) 患者的肿瘤组织及其邻近正常组织进行菌群分析和转录组测序。在PTC、BTN及其邻近无肿瘤组织中鉴定出明显不同的菌群特征。我们通过免疫组化染色、细菌原位杂交和电镜观察验证了甲状腺组织内细菌的存在。与BTN相比,我们发现在PTC中有17个菌属存在显著丰度差异,其中PTC中富集菌Rhodococcus、Neisseria、Streptococcus、Halomonas和Devosia存在促癌作用;以及丰度降低的Amycolatopsis则可能有抑癌作用。这些丰度存在明显差异的细菌可以鉴别PTC组织(PTC-T)与BTN组织(BTN-T),曲线下面积(AUC)为81.66%。微生物网络分析表明,PTC组织内细菌间的相互关联性高于BTN组织。同时,在合并桥本甲状腺炎组织的PTC中发现与免疫相关的菌属(Erwinia、Bacillus 和 Acinetobacter)明显富集。此外,我们联合转录组测序分析提示PTC富集菌与肿瘤相关信号通路的关键基因如BRAF、KRAS、IRAK4、CTNNB1、PIK3CA、MAP3K7 和 EGFR存在正相关性。总的来说,我们的研究结果表明,甲状腺肿瘤组织内存在菌群失调,并可能通过肿瘤相关信号通路参与PTC的发生。
洪磊,李兆新,陈超,郭正龙,王蔚芳,雷霁霖
《中国工程科学》 2014年 第16卷 第9期 页码 86-92
采用组织学、形态学及电化学等技术方法,研究了人工养殖条件下美洲鲥鱼雌性亲鱼卵巢发育和性类固醇激素的周期变化规律。结果表明,美洲鲥鱼属于非同步分批产卵类型;根据卵巢外部形状大小及色泽等的不同,可将美洲鲥鱼卵巢发育过程分为6 个时期;根据卵母细胞的形态结构、卵黄物质的积累和滤泡细胞的变化,将卵子发生划分为6 个时相;卵巢周期变化过程中,肝脏指数(HSI)和肥满度(CF)变化不显著,性腺指数(GSI)与血浆中雌二醇(E2)水平表现出与性腺发育协同一致的变化规律。
Progress and challenges in RET-targeted cancer therapy
《医学前沿(英文)》 2023年 第17卷 第2期 页码 207-219 doi: 10.1007/s11684-023-0985-y
关键词: pralsetinib selpercatinib RET-alteration lung cancer thyroid cancer tumor-agnostic therapy drug resistance
标题 作者 时间 类型 操作
Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism
Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani
期刊论文
Sensitivity of supplementation of thyroid hormone on treatment of idiopathic short-stature children duringtherapy with recombinant human growth hormone
Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng
期刊论文
The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid
null
期刊论文
Clinical evaluation of recombinant human growth hormone injection in children with growth hormone deficiency
Ling HOU, Xiaoping LUO, Minlian DU, Huamei MA, Chunxiu GONG, Yuchuan LI, Shuixian SHEN, Zhuhui ZHAO, Li LIANG, Guanping DONG, Chaoying YAN, Hongwei DU
期刊论文
How to judge the association of postmenopausal hormone therapy and the risk of breast cancer
Ling XU
期刊论文
Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern
null
期刊论文
RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC
期刊论文
RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC
Yinglin JI, Mingyang XU, Aide WANG
期刊论文
Analyses of levels of thyroid hormones and its receptor expression in puerperants and newborns from an
JU Ying, CHEN Lan, JIANG Qi, YANG Kedi, CHEN Xuemin, XU Guojian, LI Liping
期刊论文
mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid
期刊论文
甲状腺乳头状癌菌群失调及与肿瘤信号通路异常的相关性研究
喻爽, 丁彦强, 王雪洁, Siu Kin Ng, 曹思婷, 刘伟鑫, 郭朱明, 谢宇彬, 洪澍彬, 许丽霞, 李晓星, 李杰, 吕伟明, 彭穗, 李延兵, 沈祖尧, 于君, 肖海鹏
期刊论文